NICKEL-CATALYZED SUBSTITUTIONS OF ARYL TERT-BUTYL SULFONES WITH ORGANOMETALLIC REAGENTS - SYNTHESIS OF ORTHO-SUBSTITUTED UNSYMMETRICAL BIARYLS

被引：46

作者：

CLAYDEN, J ^{[1
]}

COONEY, JJA ^{[1
]}

JULIA, M ^{[1
]}

机构：

[1] ECOLE NORMALE SUPER,CHIM LAB,F-75231 PARIS 05,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 01期

关键词：

D O I：

10.1039/p19950000007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of a nickel salt, aryl tert-butyl sulfones react with aryl Grignard reagents to give biaryls. This reaction is used in conjunction with the powerful ortho-lithiation-directing ability of aryl tert-butyl sulfonyl groups to make-unsymmetrical ortho-substituted biaryls. In certain cases, the substitution of an aryl alkylsulfonyl group by an organometallic reagent is possible without a Transition metal catalyst.

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页码：7 / 14

页数：8

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