EVIDENCE FOR PRESYNAPTIC CHOLINERGIC RECEPTORS ON DOPAMINEGIC TERMINALS - DEGENERATION STUDIES WITH 6-HYDROXYDOPAMINE

被引：55

作者：

DEBELLEROCHE, J

LUGMANI, Y

BRADFORD, HF

机构：

[1] Department of Biochemistry, Imperial College, London

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 02期

关键词：

D O I：

10.1016/0304-3940(79)90130-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraventricular injections of 6-hydroxydopamine (6-OHDA) caused a significant decrease in the tyrosine hydroxylase of striatal synaptosomes of rats, without influencing GABA levels. Significant decreases in the muscarinic and nicotinic receptors also occurred in this preparation after 3 days. The receptors were measured by specific binding studies with N-methylatropine and α-bungarotoxin respectively. These results indicate that muscarinic and nicotinic receptors are located on the dopaminergic nerve terminals of corpus striatum. © 1979.

引用

页码：209 / 213

页数：5

共 13 条

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