A MODEL FOR IONTOPHORESIS INCORPORATING THE EFFECT OF CONVECTIVE SOLVENT FLOW

被引：66

作者：

SRINIVASAN, V

HIGUCHI, WI

机构：

[1] Department of Pharmaceutics, University of Utah, Salt Lake City

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 60卷 / 02期

关键词：

Electro-osmosis; Iontophoresis; Polypeptide; Solvent flow;

D O I：

10.1016/0378-5173(90)90298-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A model for iontophoretic transport is proposed which incorporates the effects of the applied electric field and the induced convective solvent flow, with a linear term to account for the effect of solvent flow on the permeant flux. The predictions of this model are compared with those of a model without the convective solvent flow term. The new model provides a more detailed framework to decouple and understand the interactions of the applied field and the solvent flow effects. Some interesting features of this model, which are of basic as well as practical significance, are discussed. © 1990.

引用

页码：133 / 138

页数：6

共 17 条

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[2]

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[3]

BIRD RB, 1960, TRANSPORT PHENOMENA, P646

[4]

BOCKRIS JO, 1970, MODERN ELECTROCHEMIS, V2, P826