EFFECTS OF DEXMEDETOMIDINE ON CONTRACTILITY, RELAXATION, AND INTRACELLULAR CALCIUM TRANSIENTS OF ISOLATED VENTRICULAR MYOCARDIUM

被引:60
作者
HOUSMANS, PR [1 ]
机构
[1] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN 55905
关键词
aequorin; alpha[!sub]2[!/sub]-adrenoceptor agonist; calcium; dexmedetomidine; heart; contractility; relaxation; ions; sympathetic nervous system;
D O I
10.1097/00000542-199011000-00020
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The effects of the highly selective alpha2-adrenoceptor agonist dexmedetomidine on contractility, relaxation, and the intracellular Ca2+ transients of isolated ventricular myocardium were studied in isolated right ventricular papillary muscles obtained from reserpinized ferrets. Dexmedetomidine (10-10-10-5 M) did not alter amplitude and time variables of isometric, isotonic and zero-load-clamped twitches, except for a slight increase in maximal isotonic relaxation rate at 10-5 M. Dexmedetomidine (10-8-10-5 M) caused no changes in the intracellular Ca2+ transient detected with aequorin. These results suggest that dexmedetomidine has no intrinsic myocardial contractile effects.
引用
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页码:919 / 922
页数:4
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