MEMORY RETRIEVAL ENHANCEMENT BY LOCUS-COERULEUS STIMULATION - EVIDENCE FOR MEDIATION BY BETA-RECEPTORS

被引：121

作者：

DEVAUGES, V ^{[1
]}

SARA, SJ ^{[1
]}

机构：

[1] CNRS,DEPT PSYCHOPHYSIOL,PHYSIOL NERVEUSE LAB,F-91190 GIF SUR YVETTE,FRANCE

来源：

BEHAVIOURAL BRAIN RESEARCH | 1991年 / 43卷 / 01期

关键词：

LOCUS COERULEUS; NORADRENALINE; PROPRANOLOL; MEMORY-BETA-RECEPTOR; FORGETTING;

D O I：

10.1016/S0166-4328(05)80056-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rats were trained in a complex food-motivated maze task, then implanted with indwelling stimulating electrodes in the noradrenergic nucleus locus coeruleus (LC). When tested 4 weeks later, they showed significant forgetting. Electrical stimulation of the LC alleviated forgetting in that stimulated rats made no more errors during the test than they did on the last learning trial. Systemic treatment with the beta noradrenergic antagonist propranolol blocked the effect of stimulation, suggesting that the memory facilitation is mediated through a beta-receptor.

引用

页码：93 / 97

页数：5

共 9 条

[1] ELECTROPHYSIOLOGICAL CHARACTERIZATION OF ADRENOCEPTORS IN THE RAT DORSAL HIPPOCAMPUS .2. RECEPTORS MEDIATING THE EFFECT OF SYNAPTICALLY RELEASED NOREPINEPHRINE [J].

CURET, O ;

DEMONTIGNY, C .

BRAIN RESEARCH, 1988, 475 (01) :47-57

[2] LOCUS COERULEUS POTENTIATION OF DENTATE GYRUS RESPONSES - EVIDENCE FOR 2 SYSTEMS [J].

HARLEY, C ;

MILWAY, JS ;

LACAILLE, JC .

BRAIN RESEARCH BULLETIN, 1989, 22 (04) :643-650

[3] PRIMING STIMULATION OF LOCUS COERULEUS FACILITATES MEMORY RETRIEVAL IN THE RAT [J].

SARA, SJ ;

DEVAUGES, V .

BRAIN RESEARCH, 1988, 438 (1-2) :299-303

[4] NORADRENERGIC MODULATION OF SELECTIVE ATTENTION - ITS ROLE IN MEMORY RETRIEVAL [J].

SARA, SJ .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 444 (MAY) :178-193

[5] IDAZOXAN, AN ALPHA-2 ANTAGONIST, FACILITATES MEMORY RETRIEVAL IN THE RAT [J].

SARA, SJ ;

DEVAUGES, V .

BEHAVIORAL AND NEURAL BIOLOGY, 1989, 51 (03) :401-411

[6] ACTION OF NOREPINEPHRINE IN RAT HIPPOCAMPUS .3. HIPPOCAMPAL CELLULAR RESPONSES TO LOCUS COERULEUS STIMULATION IN AWAKE RAT [J].

SEGAL, M ;

BLOOM, FE .

BRAIN RESEARCH, 1976, 107 (03) :499-511

[7] PERIPHERAL, AUTONOMIC REGULATION OF LOCUS-COERULEUS NORADRENERGIC NEURONS IN BRAIN - PUTATIVE IMPLICATIONS FOR PSYCHIATRY AND PSYCHOPHARMACOLOGY [J].

SVENSSON, TH .

PSYCHOPHARMACOLOGY, 1987, 92 (01) :1-7

[8] LABELED NORADRENALINE RELEASE FROM RAT CEREBRAL-CORTEX FOLLOWING ELECTRICAL-STIMULATION OF LOCUS COERULEUS [J].

TANAKA, C ;

INAGAKI, C ;

FUJIWARA, H .

BRAIN RESEARCH, 1976, 106 (02) :384-389

[9]

WATERHOUSE BD, 1982, J PHARMACOL EXP THER, V221, P495

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