METHYL PARATHION-INDUCED SPERM SHAPE ABNORMALITIES IN MOUSE

被引：61

作者：

MATHEW, G ^{[1
]}

VIJAYALAXMI, KK ^{[1
]}

RAHIMAN, MA ^{[1
]}

机构：

[1] MANGALORE UNIV,DEPT BIOSCI,MANGALAGANGOTHRI 574199,KARNATAKA,INDIA

来源：

MUTATION RESEARCH | 1992年 / 280卷 / 03期

关键词：

METHYL PARATHION; SWISS ALBINO MICE; SPERM SHAPE ABNORMALITY; SPERM COUNT;

D O I：

10.1016/0165-1218(92)90045-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Metacid 50, the commercial grade of methyl parathion (O,O-dimethyl-O-4-nitrophenyl phosphorothionate), a commonly used organophosphorus insecticide, was tested for its genotoxicity in Swiss albino mice using the sperm abnormality assay. Sperms of albino mice were examined at two time intervals, 1 week and 5 weeks after a single acute oral treatment with the pesticide at four dose levels, viz., 75.0, 37.5, 18.75 and 9.375 mg/kg body weight corresponding to 1/2 LD50, 1/4 LD50, 1/8 LD50 and 1/16 LD50 values respectively. A dose-related statistically significant increase in the percentage of abnormal sperm observed indicates the genotoxic potency of methyl parathion.

引用

页码：169 / 173

页数：5

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