TAUTOMERISM IN KETOMETHYL QUINOLINES .3. 4-KETOMETHYLQUINOLINES

被引：10

作者：

GREENHILL, JV ^{[1
]}

LOGHMANIKHOUZANI, H ^{[1
]}

MAITLAND, DJ ^{[1
]}

机构：

[1] UNIV BRADFORD,SCH PHARM,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1991年 / 69卷 / 04期

关键词：

KETOMETHYL QUINOLINES; PYRUVATES; TAUTOMERISM; ENOLS;

D O I：

10.1139/v91-104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 4-ketomethylquinolines has been prepared and their tautomerism investigated. The compounds were prepared from 4-methylquinoline deprotonated with lithium diisopropylamide or potassium ethoxide and treated with esters. Attempted deprotonation with tert-butyllithium or phenyllithium led to 2-substituted-4-methylquinolines. The simple alkyl or aryl 4-ketomethylquinolines exist essentially as the keto forms, but the quinoline-4-pyruvates are exclusively or substantially in the enol forms.

引用

页码：696 / 701

页数：6

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