SPHINGOFUNGIN-A, SPHINGOFUNGIN-B, SPHINGOFUNGIN-C, AND SPHINGOFUNGIN-D - A NEW FAMILY OF ANTIFUNGAL AGENTS .1. FERMENTATION, ISOLATION, AND BIOLOGICAL-ACTIVITY

被引：83

作者：

VANMIDDLESWORTH, F ^{[1
]}

GIACOBBE, RA ^{[1
]}

LOPEZ, M ^{[1
]}

GARRITY, G ^{[1
]}

BLAND, JA ^{[1
]}

BARTIZAL, K ^{[1
]}

FROMTLING, RA ^{[1
]}

POLISHOOK, J ^{[1
]}

ZWEERINK, M ^{[1
]}

EDISON, AM ^{[1
]}

ROZDILSKY, W ^{[1
]}

WILSON, KE ^{[1
]}

MONAGHAN, RL ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,POB 2000,RAHWAY,NJ 07065

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.861

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In screening for antifungal inhibitors from fungi, four related antifungal agents have been isolated from the cultivation of Aspergillus fumigatus ATCC 20857. These agents were initially produced by the microorganism growing on a solid millet-based medium. A liquid medium containing both glucose and glycerol has also been developed in which these antibiotics are produced in two phases. These novel compounds, sphingofungins A, B, C, and D, show a limited spectrum of antifungal activity but were especially effective against Cryptococcus species.

引用

页码：861 / 867

页数：7

共 18 条

[1] STRUCTURE OF THERMOZYMOCIDIN [J].