PARATHYROID HORMONE-RELATED PEPTIDE DOES NOT STIMULATE PHOSPHATE PLACENTAL TRANSPORT

被引：7

作者：

BARLET, JP

DAVICCO, MJ

ROUFFET, J

COXAM, V

LEFAIVRE, J

机构：

来源：

PLACENTA | 1994年 / 15卷 / 04期

关键词：

D O I：

10.1016/0143-4004(94)90010-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been demonstrated that parathyroid hormone-related peptide (PTHrP) stimulates calcium (Ca) placental transport. Ca and inorganic phosphorous (P) metabolisms are intimately linked. Thus we have studied the influence of PTHrP on P placental transport in ewes. In our experimental paradigm, synthetic human PTHrP (1-86) fragment intravenously injected in six single chronically catheterized fetuses (3 × 1 μg/fetus/day, from day 129 to day 140 of gestation) had no significant effect upon P placental transport which was 131 ± 6 and 129 ± 9 mg/kg fetal weight/day in treated and control fetuses, respectively. © 1994.

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页码：441 / 444

页数：4

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