MUTATION THAT IMPAIRS ABILITY OF LIPOPROTEIN RECEPTORS TO LOCALIZE IN COATED PITS ON CELL-SURFACE OF HUMAN FIBROBLASTS

被引：247

作者：

ANDERSON, RGW

GOLDSTEIN, JL

BROWN, MS

机构：

[1] UNIV TEXAS, HLTH SCI CTR, DEPT CELL BIOL, HOUSTON, TX 77030 USA

[2] UNIV TEXAS, HLTH SCI CTR, DEPT INTERNAL MED, HOUSTON, TX 77030 USA

来源：

NATURE | 1977年 / 270卷 / 5639期

关键词：

D O I：

10.1038/270695a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：695 / 699

页数：5

共 27 条

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[2] LOCALIZATION OF LOW-DENSITY LIPOPROTEIN RECEPTORS ON PLASMA-MEMBRANE OF NORMAL HUMAN FIBROBLASTS AND THEIR ABSENCE IN CELLS FROM A FAMILIAL HYPERCHOLESTEROLEMIA HOMOZYGOTE [J].

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[3] MAMMALIAN PLASMA-MEMBRANES [J].

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[4] ANALYSIS OF A MUTANT STRAIN OF HUMAN FIBROBLASTS WITH A DEFECT IN INTERNALIZATION OF RECEPTOR-BOUND LOW-DENSITY LIPOPROTEIN [J].

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[5]

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[6] FAMILIAL HYPERCHOLESTEROLEMIA - DEFECTIVE BINDING OF LIPOPROTEINS TO CULTURED FIBROBLASTS ASSOCIATED WITH IMPAIRED REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY [J].

BROWN, MS ;

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[7] RECEPTOR-MEDIATED CONTROL OF CHOLESTEROL-METABOLISM [J].

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[8]

BROWN MS, 1976, NEW ENGL J MED, V294, P1386

[9] I125 LABELED HUMAN EPIDERMAL GROWTH-FACTOR - BINDING, INTERNALIZATION, AND DEGRADATION IN HUMAN FIBROBLASTS [J].

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COHEN, S .

JOURNAL OF CELL BIOLOGY, 1976, 71 (01) :159-171

[10] SURFACE SPECIALIZATIONS OF ABSORBING CELLS [J].

FAWCETT, DW .

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