EFFECT OF CARCINOGENIC NITROSAMINES AND NITROSAMIDES ON INCORPORATION OF 3H-THYMIDINE 3H-URIDINE AND 3H-LEUCINE INTO TETRAHYMENA L-CELLS AND LIVER EXPLANTS

被引：6

作者：

VOLM, M

SUSS, R

机构：

来源：

NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE | 1968年 / 261卷 / 04期

关键词：

Carcinogenic Nitrosocompounds; DNA; RNA and Proteinsynthesis; Tetrahymena;

D O I：

10.1007/BF00537180

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of nitrosamines (diethylnitrosamine, dinitrosopiperazine) and nitrosamides (methyl-nitrosourea, ethyl-nitroso-urethane) (10-2 to 10-5 M final concentration) were tested on Tetrahymena pyriformis, L-cells and liver explants. Tetrahymena and L-cells were unaffected by the nitrosamines as far as DNA, RNA, protein synthesis and respiration were concerned. Nitrosamides however were active: DNA-, RNA-, protein synthesis and respiration reacted to different degrees. On the other hand, DNA synthesis of liver explants was inhibited by nitrosamines as well as by nitrosamides. © 1968 Springer-Verlag.

引用

页码：353 / &

共 13 条

[1] MICROSOMAL N-DEMETHYLATION AND THE EFFECT OF THE HEPATIC CARCINOGEN DIMETHYLNITROSAMINE ON AMINO ACID INCORPORTATION INTO THE PROTEINS OF RAT LIVERS AND HEPATOMAS [J].