EFFECTS OF CONDITIONS FAVORING ENZYME PHOSPHORYLATION AND DEPHOSPHORYLATION ON THE ACTIVITY OF THE ALPHA-KETO ACID DEHYDROGENASES, WITH PARTICULAR REFERENCE TO THE BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE-ACTIVITIES

被引：16

作者：

GUBLER, CJ

MALQUIST, RL

机构：

[1] Graduate Section, Biochemistry Brigham Young University Provo

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91791-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

These studies have shown that in the crude system of rat liver mitochondria the branched-chain α-keto acid dehydrogenase activities are activated at high (10.0mM) Mg++ concentrations favoring dephosphorylation, and are inactive at low (1.0mM) Mg++ concentrations favoring phosphorylation. In this crude system, α-Ketoglutarate dehydrogenase activity was also regulated in this manner. In general, the optimum Mg++ and ATP levels for activation were 10mM and 1.0mM respectively. © 1979.

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页码：855 / 861

页数：7

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