SERUM AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE REFLECTS REPAIR AFTER ACUTE MYOCARDIAL-INFARCTION

被引:71
作者
JENSEN, LT
HORSLEVPETERSEN, K
TOFT, P
BENTSEN, KD
GRANDE, P
SIMONSEN, EE
LORENZEN, I
机构
[1] HVIDOVRE UNIV HOSP,DEPT MED,DIV RHEUMATOL,DK-2650 HVIDOVRE,DENMARK
[2] HADERSLEV SYGEHUS,DEPT MED,HADERSLEV,DENMARK
[3] UNIV COPENHAGEN,RIGSHOSP,MED DEPT B,DK-2100 COPENHAGEN O,DENMARK
关键词
Myocardial infarction; Peptides; Procollagen;
D O I
10.1161/01.CIR.81.1.52
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p<0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (ρ=0.60, p=0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.
引用
收藏
页码:52 / 57
页数:6
相关论文
共 31 条
  • [1] ANTINNEN H, 1981, EUR J CLIN INVEST, V11, P75
  • [2] BENTSEN KD, 1988, ACTA CHIR SCAND, V154, P97
  • [3] IS THE AMINOTERMINAL PROPEPTIDE OF TYPE-III PROCOLLAGEN DEGRADED IN THE LIVER - A STUDY OF TYPE-III PROCOLLAGEN PEPTIDE IN SERUM DURING LIVER-TRANSPLANTATION IN PIGS
    BENTSEN, KD
    BOESBY, S
    KIRKEGAARD, P
    HANSEN, CP
    JENSEN, SL
    HORSLEVPETERSEN, K
    LORENZEN, I
    [J]. JOURNAL OF HEPATOLOGY, 1988, 6 (02) : 144 - 150
  • [4] EARLY DEGRADATION OF COLLAGEN AFTER ACUTE MYOCARDIAL-INFARCTION IN THE RAT
    CANNON, RO
    BUTANY, JW
    MCMANUS, BM
    SPEIR, E
    KRAVITZ, AB
    BOLLI, R
    FERRANS, VJ
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1983, 52 (03) : 390 - 395
  • [5] GRANDE P, 1983, SCAND J CLIN LAB INV, V43, P197
  • [6] ESTIMATION OF ACUTE MYOCARDIAL INFARCT SIZE IN MAN BY SERUM CK-MB MEASUREMENTS
    GRANDE, P
    HANSEN, BF
    CHRISTIANSEN, C
    NAESTOFT, J
    [J]. CIRCULATION, 1982, 65 (04) : 756 - 764
  • [7] HAUKIPURO K, 1988, ANN SURG, V6, P752
  • [8] SERUM AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE - RELATION TO BIOSYNTHESIS OF COLLAGEN TYPE-III IN EXPERIMENTALLY INDUCED GRANULATION-TISSUE IN RATS
    HORSLEVPETERSEN, K
    KIM, KY
    PEDERSEN, LR
    BENTSEN, KD
    ULDBJERG, N
    OXLUND, H
    GARBARSCH, C
    HAHN, EG
    SCHUPPAN, D
    LORENZEN, I
    [J]. APMIS, 1988, 96 (09) : 793 - 804
  • [9] COLLAGEN TYPE-IV AND PROCOLLAGEN TYPE-III DURING GRANULATION-TISSUE FORMATION - A SEROLOGICAL, BIOCHEMICAL, IMMUNOHISTOCHEMICAL AND MORPHOMETRICAL STUDY ON THE VISCOSE CELLULOSE SPONGE RAT MODEL
    HORSLEVPETERSEN, K
    PEDERSEN, LR
    BENTSEN, KD
    BROCKS, D
    GARBARSCH, C
    KIM, KY
    HAHN, EG
    SCHUPPAN, D
    LORENZEN, I
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1988, 18 (04) : 352 - 359
  • [10] SERUM AMINO-TERMINAL TYPE-III PROCOLLAGEN PEPTIDE IN RHEUMATOID-ARTHRITIS - RELATIONSHIP TO DISEASE-ACTIVITY, TREATMENT, AND DEVELOPMENT OF JOINT EROSIONS
    HORSLEVPETERSEN, K
    BENTSEN, KD
    JUNKER, P
    LORENZEN, I
    [J]. ARTHRITIS AND RHEUMATISM, 1986, 29 (05): : 592 - 599