ACTIVATION OF MEMBRANE NA+-K+-ATPASE OF MOUSE SKELETAL-MUSCLE BY ACETYLCHOLINE AND ITS INHIBITION BY ALPHA-BUNGAROTOXIN, CURARE AND ATROPINE

被引：44

作者：

DLOUHA, H

TEISINGER, J

VYSKOCIL, F

机构：

[1] Institute of Physiology, Czechoslovak Academy of Sciences, Videňská, 1083

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1979年 / 380卷 / 01期

关键词：

acetylcholine; atropine; electrogenic pump; Na[!sup]+[!/sup]/K[!sup]+[!/sup]-ATPase; skeletal muscles; α-bungarotoxin;

D O I：

10.1007/BF00582620

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effect of acetylcholine and of three cholinolytic compounds (α-bungarotoxin, curare and atropine) on electrogenic Na+/K+ pump and activity of the membrane Na+/K+-ATPase of mouse skeletal muscles was studied. It was found that acetylcholine potentiated both the muscle electrogenic ionic pump and the Na+/K+-ATPase activity of crude membrane fractions. The cholinolytic drugs had inhibitory effects on both parameters, with the exception of curare which was ineffective in blocking the electrogenic ionic pump. © 1979 Springer-Verlag.

引用

页码：101 / 104

页数：4

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