LIPOGENESIS IN THE DEVELOPING BRAIN - UTILIZATION OF RADIOACTIVE LEUCINE, ISOLEUCINE, OCTANOIC-ACID AND BETA-HYDROXYBUTYRIC ACID

被引：15

作者：

DHOPESHWARKAR, GA ^{[1
]}

SUBRAMANIAN, C ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, NUCL MED & RADIAT BIOL LAB, LOS ANGELES, CA 90024 USA

来源：

LIPIDS | 1979年 / 14卷 / 01期

关键词：

D O I：

10.1007/BF02533565

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incorporation of radioactivity from intracranially injected radioactive leucine, isoleucine (ketogenic amino acids), octanoic acid and .beta.-hydroxybutyric acid into the brain lipids of 15-16 day old rats was examined. Radioactivity from all these precursors was incorporated into brain lipids. Radioactivity from injected isoleucine was incorporated into odd numbered fatty acids indicating an alternate pathway to .alpha.-oxidation for the biosynthesis of these fatty acids in the brain. For some as yet unclear reasons, a substantial portion of the radioactivity from injected octanoic acid was incorporated into free fatty acids. Utilization of these compounds for providing C for lipogenesis during development under unstressed normal conditions is discussed.

引用

页码：47 / 51

页数：5

共 18 条

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