INCREASED ACTIVITY OF SUPEROXIDE-DISMUTASE IN KINDLED BRAIN AND SUPPRESSION OF KINDLED SEIZURE FOLLOWING INTRA-AMYGDALOID INJECTION OF SUPEROXIDE-DISMUTASE IN RATS

被引：30

作者：

MORI, N

WADA, JA

WATANABE, M

KUMASHIRO, H

机构：

[1] UNIV BRITISH COLUMBIA,DIV NEUROSCI,VANCOUVER V6T 2A1,BC,CANADA

[2] FUKUSHIMA MED SCH,DEPT NEUROPSYCHIAT,FUKUSHIMA 960,JAPAN

[3] UNIV BRITISH COLUMBIA,DIV NEUROL,VANCOUVER V6T 1W5,BC,CANADA

来源：

BRAIN RESEARCH | 1991年 / 557卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

SUPEROXIDE DISMUTASE; AMYGDALA; KINDLING; OXYGEN RADICAL; SEIZURE SUSCEPTIBILITY; ELEVATION OF SEIZURE THRESHOLD;

D O I：

10.1016/0006-8993(91)90151-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possible role played by superoxide dismutase (SOD), a major defense system for counteracting the toxic effects of oxygen free radicals, in amygdaloid (AM) kindling was examined in rats. A significant increase of total SOD activity in the whole brain was observed 30 days after completion of AM kindling. Intra-AM injection of 3 ng of one of the 2 SOD enzymes present in mammalian brain, i.e. cytosolic SOD containing copper and zinc (CuZn-SOD) caused suppression of kindled seizure. These results suggest that SOD participates in the presistence of AM kindled seizure susceptibility and the initiation of kindled AM seizure.

引用

页码：313 / 315

页数：3

共 19 条

[1] TRANSIENT FORMATION OF SUPEROXIDE RADICALS IN POLY-UNSATURATED FATTY ACID-INDUCED BRAIN-SWELLING [J].