IONIC LEAD, A UNIQUE METAL-ION AS AN INHIBITOR FOR CYTOCHROME P450IA2 (CYP1A2) EXPRESSION IN THE RAT-LIVER

被引：23

作者：

DEGAWA, M

ARAI, H

KUBOTA, M

HASHIMOTO, Y

机构：

[1] Department of Hygienic Chemistry, Pharmaceutical Institute, Tohoku University, Aramaki-aza Aoba Ku

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male F344 rats were treated with lead nitrate, nickel chloride, cobalt chloride or cadmium chloride, and changes in the expression of cytochrome P450IA2 (CYP1A2) in the livers were assessed by enzymatical, immunochemical, and molecular biological methods. All ionic metals used significantly decreased total CYP amount in the liver microsomes. However, among ionic metals used only lead showed inhibitory effects on the microsomal activity for CYP1A2-dependent mutagenesis of aromatic amines and on the expression of mRNA and protein of the enzyme, indicating that ionic lead is a unique inhibitor for the expression of CYP1A2 enzyme in the rat liver. (C) 1994 Academic Press, Inc.

引用

页码：1086 / 1092

页数：7

共 20 条

[1] HEME PRODUCTION IN ANIMAL-TISSUES - THE REGULATION OF BIOGENESIS OF DELTA-AMINOLEVULINATE SYNTHASE [J].