PBDX IS THE XG BLOOD-GROUP GENE

被引：56

作者：

ELLIS, NA

TIPPETT, P

PETTY, A

REID, M

WELLER, PA

YE, TZ

GERMAN, J

GOODFELLOW, PN

THOMAS, S

BANTING, G

机构：

[1] MRC, BLOOD GRP UNIT, LONDON NW1 2HE, ENGLAND

[2] UNIV CAMBRIDGE, DEPT GENET, CAMBRIDGE CB2 3EH, ENGLAND

[3] UNIV BRISTOL, SCH MED SCI, DEPT BIOCHEM, BRISTOL 1TD, AVON, ENGLAND

[4] UNIV BRISTOL, SCH MED SCI, DEPT SCI, BRISTOL 1TD, AVON, ENGLAND

[5] UNIV BRISTOL, SCH MED SCI, CTR MOLEC RECOGNIT, ENGN RES COUNCIL, BRISTOL 1TD, AVON, ENGLAND

来源：

NATURE GENETICS | 1994年 / 8卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng1194-285

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have identified the Xg(a) antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as PBDX. in indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a-) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xg(a). Therefore, by its identity with PBDX, Xg(a) is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of MIC2 which is tightly linked to XG. PBDX is renamed here XG.

引用

页码：285 / 290

页数：6

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