HOW SPECIFIC IS THE FIRST RECOGNITION STEP OF HOMOLOGOUS RECOMBINATION

被引：26

作者：

RAO, BJ ^{[1
]}

CHIU, SK ^{[1
]}

BAZEMORE, LR ^{[1
]}

REDDY, G ^{[1
]}

RADDING, CM ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(00)88976-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Escherichia coli RecA protein promotes homologous recognition in base triplets via non-Watson-Crick bonds that differ from those formed nonenzymically from DNA consisting of runs of purines or pyrimidines. Base substitutions reveal recognition to be permissive, consistent with a search for homology that achieves speed at the cost of precision.

引用

页码：109 / 113

页数：5

共 39 条

[1] STABLE SYNAPSIS OF HOMOLOGOUS DNA-MOLECULES MEDIATED BY THE ESCHERICHIA-COLI RECA PROTEIN INVOLVES LOCAL EXCHANGE OF DNA STRANDS [J].

ADZUMA, K .

GENES & DEVELOPMENT, 1992, 6 (09) :1679-1694

[2] UPTAKE OF HOMOLOGOUS SINGLE-STRANDED FRAGMENTS BY SUPERHELICAL DNA .2. CHARACTERIZATION OF REACTION [J].

BEATTIE, KL ;

WIEGAND, RC ;

RADDING, CM .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 116 (04) :783-803

[3] INSERTIONS, DELETIONS AND MISMATCHES IN HETERODUPLEX DNA MADE BY RECA-PROTEIN [J].

BIANCHI, ME ;

RADDING, CM .

CELL, 1983, 35 (02) :511-520

[4] 3-STRANDED PARANEMIC JOINTS - ARCHITECTURE, TOPOLOGICAL CONSTRAINTS AND MOVEMENT [J].

BORTNER, C ;

GRIFFITH, J .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (04) :623-634

[5] INTERACTIONS OF 3 STRANDS IN JOINTS MADE BY RECA PROTEIN [J].

CHIU, SK ;

RAO, BJ ;

STORY, RM ;

RADDING, CM .

BIOCHEMISTRY, 1993, 32 (48) :13146-13155

[6] SITE-SPECIFIC OLIGONUCLEOTIDE BINDING REPRESSES TRANSCRIPTION OF THE HUMAN C-MYC GENE INVITRO [J].

COONEY, M ;

CZERNUSZEWICZ, G ;

POSTEL, EH ;

FLINT, SJ ;

HOGAN, ME .

SCIENCE, 1988, 241 (4864) :456-459

[7] WHY DOES RECA PROTEIN HYDROLYZE ATP [J].

COX, MM .

TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (05) :217-222

[8] LOWER FIDELITY OF RECA PROTEIN CATALYZED HOMOLOGOUS PAIRING WITH A SUPERHELICAL SUBSTRATE [J].

DASGUPTA, C ;

RADDING, CM .

NATURE, 1982, 295 (5844) :71-73

[9] POLAR BRANCH MIGRATION PROMOTED BY RECA-PROTEIN - EFFECT OF MISMATCHED BASE-PAIRS [J].

DASGUPTA, C ;

RADDING, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (03) :762-766

[10] FORMATION OF A THREE-STRANDED POLYNUCLEOTIDE MOLECULE [J].

FELSENFELD, G ;

DAVIES, DR ;

RICH, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (08) :2023-2024

← 1 2 3 4 →