IS THE TRIMODALITY OF HB LESLIE (ALPHA-2-BETA-2 131GLN-]O) IN HETEROZYGOTES THE RESULT OF A VARIABLE NUMBER OF ACTIVE ALPHA-CHAIN GENES - EVIDENCE FOR POST-TRANSLATIONAL CONTROL OF HEMOGLOBIN SYNTHESIS

被引：10

作者：

FELICE, A

ABRAHAM, EC

MILLER, A

STALLINGS, M

HUISMAN, THJ

机构：

[1] MED COLL GEORGIA,CTR COMPREHENS SICKLE CELL,DEPT CELL & MOLEC BIOL,AUGUSTA,GA 30901

[2] MED COLL GEORGIA,DEPT MED,AUGUSTA,GA 30901

[3] VET ADM HOSP,AUGUSTA,GA 30904

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1978年 / 5卷 / 01期

关键词：

D O I：

10.1002/ajh.2830050102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1 / 9

页数：9

共 13 条

[1]

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RINGELHANN, B ;

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Mirsky, AE .

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DESIMONE, J ;

KLEVE, L ;

LONGLEY, MA ;

SHAEFFER, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 57 (01) :248-254

[6] UNBALANCED GLOBIN CHAIN SYNTHESIS IN RETICULOCYTES OF SICKLE-CELL TRAIT INDIVIDUALS WITH LOW CONCENTRATIONS OF HEMOGLOBIN-S [J].

DESIMONE, J ;

KLEVE, L ;

LONGLEY, MA ;

SHAEFFER, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 59 (02) :564-569

[7] SOLUBLE ATP-DEPENDENT PROTEOLYTIC SYSTEM RESPONSIBLE FOR DEGRADATION OF ABNORMAL PROTEINS IN RETICULOCYTES [J].

ETLINGER, JD ;

GOLDBERG, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (01) :54-58

[8]

FELICE A, 1978, RED CELL, P131

[9] TRIMODALITY IN PERCENTAGES OF BETA-CHAIN VARIANTS IN HETEROZYGOTES - EFFECT OF NUMBER OF ACTIVE HB-ALPHA STRUCTURAL LOCI [J].

HUISMAN, THJ .

HEMOGLOBIN, 1977, 1 (04) :349-382

[10]

Huisman THJ, 1977, HEMOGLOBINOPATHIES T

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