MECHANISM OF PLATEAU FORMATION BY ANEMONE TOXIN

被引：3

作者：

LILLEHEIL, G

SHAPIRO, BI

机构：

[1] Norwegian Defence Research Establishment, Division for Toxicology

[2] The Biological Laboratories, Harvard University

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY | 1969年 / 30卷 / 02期

关键词：

Anemone toxin; Condylactis gigantea; lobster axon; sodium inactivation; toxin;

D O I：

10.1016/0010-406X(69)90811-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. The cause of plateau formation in neurons poisoned by anemone toxin was investigated. 2. 2. Membrane resistance measurements in crustacean neurons disclosed low resistance plateaus. 3. 3. Sufficient transmembrane current pulses in hyperpolarizing direction terminated the plateaus. This current threshold showed a gradual decrease during the plateau. 4. 4. The shape of the plateaus was altered by changes in ionic composition of the perfusing medium. The effects were those expected if the plateaus were caused by the passage of residual sodium current. 5. 5. The simplest hypothesis in accordance with Hodgkin-Huxley theory seems to be that the toxin merely increases the time constant of sodium inactivation. © 1969.

引用

页码：281 / +

页数：1

共 15 条

[1] RESPONSE OF SINGLE MOTONEURONS TO DIRECT STIMULATION IN TOADS SPINAL CORD [J].