2-(3-LITHIOPROPYL) AND 2-(3-LITHIOPROPYL)-2-METHYL-1,3-DIOXOLANE - NEW MASKED LITHIUM BISHOMOENOLATES IN THE SYNTHESIS OF BIFUNCTIONALIZED COMPOUNDS

2-(3-Lithiopropyl)- and 2-(3-lithiopropyl)-2-methyl-1,3-dioxolane (2) are prepaned by lithiation of the corresponding chlorinated precursors with lithium naphthalenide at -78°C. The reaction of these masked bishomoenolates with different electrophiles yields the expected monoprotected functional carbonyl compounds (3-12), which can be easily deprotected under acid conditions. © 1990.