ISOLATION AND STRUCTURE DETERMINATION OF ENZYMATICALLY FORMED STYRENE OXIDE GLUTATHIONE CONJUGATES

被引：30

作者：

PACHECKA, J ^{[1
]}

GARIBOLDI, P ^{[1
]}

CANTONI, L ^{[1
]}

BELVEDERE, G ^{[1
]}

MUSSINI, E ^{[1
]}

SALMONA, M ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI,VIA ERITREA 62,I-20157 MILAN,ITALY

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 27卷 / 2-3期

关键词：

D O I：

10.1016/0009-2797(79)90134-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When styrene oxide was incubated with glutathione in the presence of rat liver cytosolic fraction, two conjugates were formed. Structural investigation by mass spectrometry (MS), proton magnetic resonance (PMR) analysis and chemical fragmentation showed the presence of two positional isomers, namely S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in a ratio of approx. 60 : 40. © 1979.

引用

页码：313 / 321

页数：9

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