LIPOXIN-A4 INHIBITS PHOSPHOINOSITIDE HYDROLYSIS IN HUMAN NEUTROPHILS

被引：48

作者：

GRANDORDY, BM

LACROIX, H

MAVOUNGOU, E

KRILIS, S

CREA, AEG

SPUR, BW

LEE, TH

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON,ENGLAND

[2] FAC COCHIN,DEPT MALAD RESP & PHYSIOL,PARIS,FRANCE

[3] ST GEORGE HOSP,DEPT MED,KOGARAH,NSW,AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90625-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoxins (LX) are trihydroxytetraene metabolites derived from arachidonic acid via an interaction between the 5- and 15-lipoxygenases. Preincubation of [3H] myo-inositol labeled PMN with 10-7M and 10-5M LXA4 for 1 minute at 37°C resulted in a concentration dependent inhibition of the generation of [3H] IP3 and [3H] IP in cells subsequently stimulated by increasing doses of LTB4 or FMLP for 1 minute at 37°C. Preincubation of PMN with LXA4 did not inhibit specific binding of [3H] LTB4 to PMN. These results indicate that LXA4 inhibits chemotactic factor-induced phosphoinositide hydrolysis at a post-receptor level. © 1990.

引用

页码：1022 / 1029

页数：8

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