ANIMAL-MODELS OF BCR ABL-INDUCED LEUKEMIAS

被引：17

作者：

DALEY, GQ

机构：

[1] Department of Medicine, Massachusetts General Hospital, Boston

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 11卷

关键词：

ANIMAL MODELS; BCR ABL-INDUCED LEUKEMIAS;

D O I：

10.3109/10428199309047865

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic myelogenous leukemia (CML) serves as a valuable paradigm for understanding the molecular genetic origins of cancer. The cytogenetic standard of diagnosis, the Philadelphia chromosome, has been superseded by a molecular definition for the disease, that of BCR/ABL gene rearrangement. The use of BCR/ABL to recreate CML in mice fulfills Koch's postulates for molecular pathogenesis. The present murine systems facilitate research into the biology of BCR/ABL-induced leukemias, but fall short in their promise to provide models for testing new therapies for CML. A transgenic strain of mice with an inheritable predisposition to CML would be an invaluable tool.

引用

页码：57 / 60

页数：4

共 11 条

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