COMPARISON OF ORGANOPHOSPHOROUS ACID ANHYDROLASES FROM DIFFERENT SPECIES USING MONOCLONAL-ANTIBODIES

被引：6

作者：

DESCHAMPS, JR ^{[1
]}

KOPECSMYTH, K ^{[1
]}

POPPINO, JL ^{[1
]}

FUTROVSKY, SL ^{[1
]}

WARD, KB ^{[1
]}

机构：

[1] WALTER REED ARMY INST RES,DIV IMMUNOL,WASHINGTON,DC 20307

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 106卷 / 03期

关键词：

D O I：

10.1016/0742-8413(93)90240-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Monoclonal antibodies were raised against squid hepatopancreas organophosphorous acid (OPA) anhydrolase (EC 3.1.8.2) and were used to study structural similarities with OPA anhydrolases isolated from different sources. 2. Common epitopes were identified in OPA anhydrolases with diverse origins, and with different substrate specificities. 3. Epitopes unique to the squid hepatopancreas OPA anhydrolase were identified; optic ganglion and hepatopancreas contain different enzymes which can be distinguished by their epitopes.

引用

页码：765 / 768

页数：4

共 8 条

[1]

CHENG T, 1990, 1989 P US ARM CHEM D, P637

[2]

DUMAS DP, 1989, J BIOL CHEM, V264, P19659

[3] COMPARISON OF DFP-HYDROLYZING ENZYME PURIFIED FROM HEAD GANGLION AND HEPATOPANCREAS OF SQUID (LOLIGO-PEALEI) BY MEANS OF ISOELECTRIC FOCUSING [J].

GARDEN, JM ;

HAUSE, SK ;

HOSKIN, FCG ;

ROUSH, AH .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1975, 52 (02) :95-98

[4] DIISOPROPHYLPHOSPHOROFLUORIDATE AND TABUN - ENZYMATIC HYDROLYSIS AND NERVE FUNCTION [J].

HOSKIN, FCG .

SCIENCE, 1971, 172 (3989) :1243-+

[5]

KOPECSMYTH K, 1990, 1989 P U SARM CHEM D, P721

[6]

LUNZER J, 1992, TRF50H0001H1500 ORD, P33

[7] HEAT-STABLE PARAOXONASE (O,O-DIETHYL O-PARA-NITROPHENYL PHOSPHATE O-PARA-NITROPHENYL HYDROLASE) FROM RUSSELLS VIPER VENOM [J].

MENDE, TJ ;

MORENO, M .

BIOCHEMISTRY, 1975, 14 (17) :3913-3916

[8]

REINER E, 1992, 2ND P INT M EST HYDR, P1

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