DETERMINATION OF OCTANOL-WATER PARTITION-COEFFICIENTS BY AN HPLC METHOD FOR ANTICONVULSANT STRUCTURE-ACTIVITY STUDIES

被引：26

作者：

HENCZI, M

NAGY, J

WEAVER, DF

机构：

[1] QUEENS UNIV,DEPT MED,KINGSTON,ON K7L 3N6,CANADA

[2] QUEENS UNIV,DEPT CHEM,KINGSTON,ON K7L 3N6,CANADA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1995年 / 47卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1995.tb05807.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Octanol-water partition coefficients have been measured and calculated for eight clinically relevant anticonvulsants. For some compounds, these are the first experimentally available log P values. For the remainder of the molecules, new values have been suggested. The utility of the micro shake-flask experimental method and the ALOGP calculational method in determining anticonvulsant log P values has been demonstrated.

引用

页码：345 / 347

页数：3

共 16 条

[1] ABBO, II
[2] ABBOTT FS, 1988, NEUROPHARMACOLOGY, V22, P875
[3] FAUCHERE JL, 1989, QSAR QUANTITATIVE ST
[4] A RAPID MICROSCALE METHOD FOR THE DETERMINATION OF PARTITION-COEFFICIENTS BY HPLC
FORD, H
MERSKI, CL
KELLEY, JA
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1991, 14 (18): : 3365 - 3386
[5] FOWLER DW, 1989, J PHARMACOL EXP THER, V249, P318
[6] ATOMIC PHYSICOCHEMICAL PARAMETERS FOR 3-DIMENSIONAL STRUCTURE DIRECTED QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS .3. MODELING HYDROPHOBIC INTERACTIONS
GHOSE, AK
PRITCHETT, A
CRIPPEN, GM
[J]. JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (01) : 80 - 90
[7] HYDROPHOBICITY AND CENTRAL-NERVOUS-SYSTEM AGENTS - ON THE PRINCIPLE OF MINIMAL HYDROPHOBICITY IN DRUG DESIGN
HANSCH, C
BJORKROTH, JP
LEO, A
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (09) : 663 - 687
[8] Hansch C., 1979, SUBSTITUENT CONSTANT
[9] DETERMINATION OF OCTANOL-WATER PARTITION-COEFFICIENTS FOR A SERIES OF IMIDAZOLIDINEDIONES BY A NOVEL COMBINATION OF MICRO SHAKE-FLASK AND HPLC TECHNIQUES
HENCZI, M
NAGY, J
WEAVER, DF
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1994, 17 (12): : 2605 - 2613
[10] HENCZI M, 1993, EXPT MEASUREMENT PAR

← 1 2 →