INDUCTION OF SUPPRESSOR CELLS BY INTRAVENOUS ADMINISTRATION OF BACILLUS CALMETTE-GUERIN AND ITS MODULATION BY CYCLOPHOSPHAMIDE

被引：11

作者：

BENNETT, JA

MITCHELL, MS

机构：

[1] YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, DEPT MED, NEW HAVEN, CT 06510 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 12期

关键词：

D O I：

10.1016/0006-2952(79)90649-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

I.v. administration of BCG [an immunologia antineoplastic agent] activated cells in [mouse] bone marrow and induced cells in the spleen, which suppressed the development of cell-mediated immunity by T [thymus-derived cells] of BCG. A course of cyclophosphamide (60 mg/kg per day) given during the 4 days preceding or following the administration of BCG potentiated the induction of suppressor cells by BCG. If the 4-day course of cyclophosphamide was not initiated until 7 days after the administration of BCG, then the induction of suppressor cells by BCG was partially reversed.

引用

页码：1947 / 1952

页数：6

共 23 条

[1] IMMUNOSUPPRESSIVE EFFECTS OF METHYLGLYOXAL-BIS(GUANYLHYDRAZONE) ON MOUSE BONE-MARROW AND SPLEEN-CELLS AND THEIR ANTAGONISM BY SPERMIDINE [J].