THE EFFECT OF DERMATAN SULFATE ON INVITRO HUMAN PLASMA COAGULATION, PLATELET-AGGREGATION AND BETA-TG/PF4 RELEASE

被引：14

作者：

COFRANCESCO, E ^{[1
]}

COLOMBI, M ^{[1
]}

GIANESE, F ^{[1
]}

CORTELLARO, M ^{[1
]}

机构：

[1] MEDIOLANUM FARMACEUT,DEPT MED,MILAN,ITALY

来源：

THROMBOSIS RESEARCH | 1990年 / 57卷 / 03期

关键词：

anticoagulant activity; Dermatan sulfate; platelet aggregation; βTG/PF4; release;

D O I：

10.1016/0049-3848(90)90256-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the in vitro anticoagulant action of dermatan sulfate (DS) (aPTT, antiXa, anti-thrombin) and its effect on human platelet aggregation and βTG/PF4 release induced by threshold doses of aggregating agents, compared with standard heparin (SH). In pooled plasma, DS prolonged aPTT much less than SH, had no measurable antiXa activity, showed an anti-thrombin activity similar to that shown by SH at a tenfold higher dilution. DS had no direct effect on human platelet aggregation and βTG/PF4 release. More-over it did not significantly affect platelet aggregation and release by ADP and collagen, whereas it completely inhibited platelet aggregation and βTG/PF4 release by thrombin. These data in vitro confirm that thrombin inhibition induced by DS is accompained by a far lesser aPTT prolongation compared to heparin, without any appreciable interference with platelet function. © 1990.

引用

页码：405 / 414

页数：10

共 32 条

[1] LOW-AFFINITY HEPARIN POTENTIATES THE ACTION OF HIGH-AFFINITY HEPARIN OLIGOSACCHARIDES [J].