RITANSERIN DECREASES PORTAL PRESSURE IN CONSCIOUS AND UNRESTRAINED CIRRHOTIC RATS

被引:29
作者
MASTAI, R [1 ]
GIROUX, L [1 ]
SEMRET, M [1 ]
HUET, PM [1 ]
机构
[1] HOP ST LUC, ANDRE VIALLET CLIN RES CTR, 264 RENE LEVESQUE E, MONTREAL H2X 1P1, QUEBEC, CANADA
关键词
D O I
10.1016/0016-5085(90)91302-M
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We have recently demonstrated that ritanserin, a serotonin 5-hydroxytrytamine receptor antagonist void of systemic effects, caused a significant reduction of portal pressure in conscious cirrhotic dogs. The mechanism by which ritanserin lowers portal pressure is poorly defined. We investigated the splanchnic and systemic hemodynamic effects of ritanserin (0.63 mg/kg body wt i.V., a dose known to completely inhibit binding of 5-hydroxytryptamine to its receptors), in conscious and unrestrained cirrhotic rats (n = 13). Heparinized catheters were placed into the portal vein, inferior vena cava, aorta, and left ventricle with exit from the neck. Hemodynamic studies were performed 4 h after consciousness was regained. Cardiac output and regional blood flows were measured using radiolabeled microspheres and the reference sample method. Sixty minutes after administration, ritanserin caused a significant reduction of portal pressure (-17%) with minimal changes in portal venous inflow (+3%). Portal vascular resistance decreased significantly (-23%), whereas splanchnic arteriolar resistance was similar before and after ritanserin. A significant increase in mean arterial pressure (+5%) and cardiac output (+22%) was observed. Our results suggest that ritanserin lowers portal pressure through a mechanism separate from portal venous inflow. This effect could be due to changes in intrahepatic or on portocollateral resistances, or both. These findings support the potential use of this new agent in the treatment of portal hypertension. © 1990.
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页码:141 / 145
页数:5
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