INVITRO EVALUATION OF CLAVULANIC ACID, A POTENT, BROAD-SPECTRUM BETA-LACTAMASE INHIBITOR

被引：29

作者：

GREENWOOD, D

OGRADY, F

BAKER, P

机构：

[1] Department of Microbiology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1979年 / 5卷 / 05期

关键词：

D O I：

10.1093/jac/5.5.539

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in vitro efficacy of clavulanic acid, a new broad-spectrum inhibitor of enterobacterial β-lactamases, was investigated. In conventional agar dilution tests, the presence of a sub-inhibitory level of clavulanic acid (8 μ/ml) lowered the minimum inhibitory concentration of ampicillin for many resistant enterobacteria to therapeutically achievable levels. When tested against dense populations of Ercherichia coli and klebsiella strains in a static turbidimetric system and in an in vitro model of the treatment of bacterial cystitis, clavulanic acid plus ampicillin suppressed bacterial growth for periods far exceeding the normal interdose interval at concentrations at which neither agent alone was effective.In addition to its activity as a β-lactamase inhibitor, clavulanic acid may interact with other β-lactam antibiotics in a second, distinct way. Because of this synergic interactions may occur with non-β-lactamase producing organisms, and the overall synergic effect obtained with β-lactamase producers may be compounded of two separate elements. © 1979, by The British Society for Antimicrobial Chemotherapy.

引用

页码：539 / 547

页数：9

共 16 条

[1]

Aldridge C., A Multichannel Instrument for Monitoring the Growth of Bacterial Cultures, (1975)

[2]

Greenwood D., O'Grady F., Comparison of the responses of Escherichia coli and Proteus mirabilis to seven ß-lactam antibiotics, Journal of Infectious Diseases, 211, 2, (1973)

[3]

Greenwood D., O'Grady F., FL 1060: A new beta-lactam antibiotic with novel properties, Journal of Clinical Pathology, 26, pp. 1-6, (1973)

[4]

Greenwood D., O'Grady F., The two sites of penicillin action in Escherichia coli, Journal of Infectious Diseases, 128, pp. 791-794, (1973)

[5]

Greenwood D., O'Grady F., Potent combinations of 8-lactam antibiotics using the ß-lacta- mase inhibition principle, Chemotherapy, 21, pp. 330-341, (1975)

[6]

Greenwood D., O'Grady F., An in vitro model of the urinary bladder, Journal of Antimicrobial Chemotherapy, 4, pp. 113-120, (1978)

[7]

Mackintosh I.P., O'Grady F., Greenwood D., Watson B.W., Crichton T.C., Piper R., Ferrer A., A twelve channel bacterial growth monitoring system, Biomedical Engineering, 514, 526, (1973)

[8]

O'Callaghan C.H., Morris A., Kirby S.M., Shingler A.H., Novel method for detection of ß-lactamasesusing a chromogenic cephalosporin substrate, Antimicrobial Agents and Chemotherapy, 1, pp. 283-288, (1972)

[9]

O'Grady F., Mackintosh I.P., Greenwood D., Watson B.W., Treatment of ‘bacterial cystitis’ in fully automatic mechanical models simulating conditions of bacterial growth in the urinary bladder, British Journal of Experimental Pathology, 54, pp. 283-290, (1973)

[10]

Reading C., Cole M., Clavulanic acid: A beta-lactamase-inhibiting beta-lactam from Strepto- myces clavuligerus, Antimicrobial Agents and Chemotherapy, 11, pp. 852-857, (1977)

← 1 2 →