EXPRESSION OF C-FOS, C-JUN, JUN-B, METALLOTHIONEIN AND METALLOPROTEINASE GENES IN HUMAN CHONDROCYTE

被引：45

作者：

ZAFARULLAH, M

MARTELPELLETIER, J

CLOUTIER, JM

GEDAMU, L

PELLETIER, JP

机构：

[1] HOP ST LUC,DEPT SURG,MONTREAL H2X 3J4,QUEBEC,CANADA

[2] UNIV CALGARY,DEPT BIOL SCI,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

FEBS LETTERS | 1992年 / 306卷 / 2-3期

关键词：

OSTEOARTHRITIS; CHONDROCYTE; FOS/JUN; COLLAGENASE; STROMELYSIN; METALLOTHIONEIN; MESSENGER RNA;

D O I：

10.1016/0014-5793(92)80992-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Normal and osteoarthritic (OA) human articular cartilage chondrocytes, released enzymatically in the presence of 0.5% fetal calf serum, display constitutive expression of early response activating protein (AP-1) genes; c-fos, c-jun and jun-B. Among the late AP-1 responsive genes, total metallothionein (MT) and stromelysin mRNAs were expressed at high levels in both normal and OA chondrocytes, while collagenase and hMT-II(A) mRNA levels were elevated only in OA individuals. Despite the common AP-1 sequences present in their promoter regions, the three late genes were differentially expressed.

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页码：169 / 172

页数：4

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