A DOUBLE-BLIND TRIAL OF BOTULINUM TOXIN-A IN TORTICOLLIS, WITH ONE YEAR FOLLOW-UP

被引：76

作者：

MOORE, AP

BLUMHARDT, LD

机构：

[1] Department of Neurological Science, University of Liverpool, Walton Hospital, Liverpool, L9 1AE, Rice Lane

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 09期

关键词：

SPASMODIC TORTICOLLIS; MOTOR NERVES; INJECTIONS;

D O I：

10.1136/jnnp.54.9.813

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A double blind placebo controlled crossover trial was performed of botulinum toxin "A" in 20 patients with spasmodic torticollis. There was a statistically significant benefit for those treated with toxin; 12 on toxin improved objectively, compared with four on placebo (p < 0.04). After a follow up period of one year, 16 still seemed to benefit from repeated toxin injections. The main side effect was dysphagia, which appeared to be dose related in individual patients.

引用

页码：813 / 816

页数：4

共 21 条

[1]

Berardelli A, 1988, Adv Neurol, V50, P525

[2] INTERACTION OF I-125 LABELED BOTULINUM NEUROTOXINS WITH NERVE-TERMINALS .1. ULTRASTRUCTURAL AUTORADIOGRAPHIC LOCALIZATION AND QUANTITATION OF DISTINCT MEMBRANE ACCEPTORS FOR TYPE-A AND TYPE-B ON MOTOR NERVES [J].