METABOLISM AND ACTION OF PURINE NUCLEOSIDE ANALOGS

被引：140

作者：

PLUNKETT, W

SAUNDERS, PP

机构：

[1] Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston

来源：

PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 03期

关键词：

D O I：

10.1016/0163-7258(91)90057-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent investigations have identified many new purine nucleoside analogs that act as antimetabolites. This article focuses on the metabolism and mechanisms of action of tiazofurin, 3-deazaguanosine, neplanocin A, arabinosyladenine in combination with inhibitors of adenosine deaminase, arabinosyl-2-fluoroadenine, and 2-chloro-2'-deoxyadenosine, drugs that are either currently being evaluated in clinical trials or are close to that stage. The diverse metabolic requirements for activation, unique mechanisms of action, and differential biological activities of these compounds are characterized and evaluated for prospective therapeutic application.

引用

页码：239 / 268

页数：30

共 345 条

[1] THE MECHANISM OF INACTIVATION OF S-ADENOSYLHOMOCYSTEINASE BY 2'-DEOXYADENOSINE [J].