METABOTROPIC RECEPTOR MEDIATED AFTERDEPOLARIZATION IN NEOCORTICAL NEURONS

被引：15

作者：

GREENE, C ^{[1
]}

SCHWINDT, P ^{[1
]}

CRILL, W ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT PHYSIOL & BIOPHYS SJ40,SEATTLE,WA 98195

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 03期

关键词：

METABOTROPIC RECEPTORS; GLUTAMATE; AFTERDEPOLARIZATION;

D O I：

10.1016/0922-4106(92)90073-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In rat neocortical slices activation of glutamate metabotropic receptors with glutamate, quisqualate and 1S,3R-ACPD caused a spike-evoked afterdepolarization which replaced the normal afterhyperpolarization. In some neocortical neurons the afterdepolarization reached action potential threshold causing prolonged self-sustained firing. These effects of metabotropic receptor activation were similar to the action of muscarinic agonists in the same preparation.

引用

页码：279 / 280

页数：2

共 6 条

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