CHANGES OF CEREBRAL VASOACTIVE INTESTINAL POLYPEPTIDE-LIKE AND SOMATOSTATIN-LIKE IMMUNOREACTIVITY INDUCED BY NOISE AND WHOLE-BODY VIBRATION IN THE RAT

被引：18

作者：

NAKAMURA, H ^{[1
]}

MOROJI, T ^{[1
]}

NAGASE, H ^{[1
]}

OKAZAWA, T ^{[1
]}

OKADA, A ^{[1
]}

机构：

[1] PSYCHIAT RES INST TOKYO, DEPT PSYCHOPHARMACOL, SETAGAYA KU, TOKYO 156, JAPAN

来源：

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY | 1994年 / 68卷 / 01期

关键词：

NOISE; SOMATOSTATIN; STRESS; VASOACTIVE INTESTINAL POLYPEPTIDE; WHOLE-BODY VIBRATION;

D O I：

10.1007/BF00599243

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To clarify the role of vasoactive intestinal polypeptide (VIP) and somatostatin, somatropin-release inhibiting factor, (SRIF) neurons in the response to organisms to noise or whole-body vibration stress, VIP- and SRIF-like immunoreactivity were determined in various regions of the rat brain following exposure for 90 min to noise (broad band, 102 dB) or whole-body vibration (20 Hz, 4.0 g). Both noise and whole-body vibration significantly increased VIP-like immunoreactivity in the amygdala. A significant reduction of VIP-like immunoreactivity in the hippocampus was induced only by whole-body vibration. On the other hand, SRIF-like immunoreactivity was decreased significantly in the hypothalamus and increased significantly in the amygdala by noise and whole-body vibration, respectively. The present findings would seem to indicate that the amygdalofugal VIP neural system is involved in regulating hypothalamic and pituitary hormone secretions in non-specific reactions to stress. Responses of hippocampal VIP and the amygdalofugal SRIF to whole-body vibration stress are assumed to be activated as specific reactions to the stress.

引用

页码：62 / 67

页数：6

共 43 条

[1] EXTRAHYPOPHYSEAL DISTRIBUTION OF ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH)-LIKE IMMUNOREACTIVITY IN POSTMORTEM BRAINS FROM NORMAL SUBJECTS AND ALZHEIMER-TYPE DEMENTIA PATIENTS [J].

ARAI, H ;

MOROJI, T ;

KOSAKA, K ;

IIZUKA, R .

BRAIN RESEARCH, 1986, 377 (02) :305-310

[2] EFFECT OF WHOLE-BODY VIBRATION ON THE RAT-BRAIN CONTENT OF SEROTONIN AND PLASMA-CORTICOSTERONE [J].

ARIIZUMI, M ;

OKADA, A .

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1983, 52 (01) :15-19

[3]

ARIIZUMI M, 1985, BRIT J IND MED, V42, P133

[4] ROLE OF ENDOGENOUS SUBSTANCE-P IN STRESS-INDUCED ACTIVATION OF MESOCORTICAL DOPAMINE NEURONS [J].

BANNON, MJ ;

ELLIOTT, PJ ;

ALPERT, JE ;

GOEDERT, M ;

IVERSEN, SD ;

IVERSEN, LL .

NATURE, 1983, 306 (5945) :791-792

[5] THE EFFECT OF SOMATOSTATIN ON STRIATAL CATECHOLAMINES [J].

BEAL, MF ;

MARTIN, JB .

NEUROSCIENCE LETTERS, 1984, 44 (03) :271-276

[6] HYPOTHALAMIC POLYPEPTIDE THAT INHIBITS SECRETION OF IMMUNOREACTIVE PITUITARY GROWTH-HORMONE [J].

BRAZEAU, P ;

VALE, W ;

BURGUS, R ;

LING, N ;

BUTCHER, M ;

RIVIER, J ;

GUILLEMIN, R .

SCIENCE, 1973, 179 (4068) :77-79

[7]

CHESSELET MF, 1983, J NEUROSCI, V3, P232

[8]

DIERICKX K, 1979, CELL TISSUE RES, V201, P349

[9] VASOACTIVE INTESTINAL PEPTIDE AS A NEUROTRANSMITTER IN THE CEREBRAL-CIRCULATION [J].

DUCKLES, SP ;

SAID, SI .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 78 (03) :371-374

[10]

DUPUIS H, 1984, WESTKREUZDRUCKEREI, V38, P265

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