EFFECTS OF MAXIMAL EXERCISE AND VENOUS OCCLUSION ON FIBRINOLYTIC-ACTIVITY IN PHYSICALLY ACTIVE AND INACTIVE MEN

被引:49
作者
SZYMANSKI, LM [1 ]
PATE, RR [1 ]
DURSTINE, JL [1 ]
机构
[1] UNIV S CAROLINA,DEPT EXERCISE SCI,COLUMBIA,SC 29208
关键词
TISSUE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR; FIBRINOLYSIS; EXERTION; PHYSICAL FITNESS;
D O I
10.1152/jappl.1994.77.5.2305
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The purposes of this study were to 1) characterize changes in fibrinolytic activity in response to maximal exercise and 5-min venous occlusion and 2) compare responses in men of various habitual physical activity levels. Tissue plasminogen activator (TPA) activity and plasminogen activator inhibitor 1 (PAI-1) activity were measured in 15 inactive, 15 regularly active, and 15 highly active men. Data were analyzed using a three-way analysis of variance with repeated measures. Pretest TPA activity was similar among groups. TPA activity increased postexercise with higher values seen in the active groups (P < 0.001). The highly active group also significantly increased TPA activity postvenous occlusion (P < 0.01). Pretest PAI-1 activity was different among groups, with the inactive group showing the highest activity and the highly active group the lowest (P < 0.05). PAI-1 activity decreased with exercise (P < 0.01) but did not change with venous occlusion. In conclusion, active men exhibited greater changes in fibrinolytic activity with maximal exercise and venous occlusion than inactive men. This enhanced fibrinolytic activity may be an important mechanism mediating the cardioprotective effect provided by regular physical activity.
引用
收藏
页码:2305 / 2310
页数:6
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