VALUE OF QUANTITATIVE SALIVARY-GLAND SCINTIGRAPHY IN THE EARLY-STAGE OF SJOGRENS-SYNDROME

被引：47

作者：

BOHUSLAVIZKI, KH

BRENNER, W

WOLF, H

SIPPEL, C

TONSHOFF, G

TINNEMEYER, S

CLAUSEN, M

HENZE, E

机构：

[1] Clinic of Nuclear Medicine, Christian-Albrechts-Universität Kiel, Kiel, D-24105

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1995年 / 16卷 / 11期

关键词：

D O I：

10.1097/00006231-199511000-00007

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

The aim of this study was to test the impact of quantitative salivary gland scintigraphy in patients with suspected Sjogren's syndrome. Thirteen patients with suspected Sjogren's syndrome were investigated. During clinical work-up, three had severe and four had mild Sjogren's syndrome, while six were normal. Quantitative salivary gland scintigraphy was performed using a standardized method. The normal database consisted of 172 patients without any evidence of salivary gland malfunction. Visual and quantitative comparisons of the patients' scintigrams were made. In the patients with severe Sjogren's syndrome, uptake was 0.10 +/- 0.04% and 0.09 +/- 0.03% in the parotid and submandibular glands respectively, confirming the visual diagnosis. In the patients without Sjogren's syndrome, concordance between the visual. and quantitative evaluations could also be shown. In contrast, among the patients with mild Sjogren's syndrome, uptake was diminished (P < 0.05), amounting to 0.21 +/- 0.05% and 0.16 +/- 0.02% in the parotid and submandibular glands respectively, while visual analysis indicated normal parenchymatous function. In conclusion, quantitative salivary gland scintigraphy is essential for the reliable detection of parenchymatous malfunction at an early stage of Sjogren's syndrome, which may be missed by visual analysis alone.

引用

页码：917 / 922

页数：6

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