ALPHA,BETA-UNSATURATED CARBOXYLIC-ACID DERIVATIVES .17. FACILE SYNTHESIS OF ETHYL ALPHA-AZIDO-ALPHA-ALKENOATES AND REDUCTION TO ETHYL ALPHA-AMINO-ALPHA-ALKENOATES

被引：23

作者：

SHIN, C ^{[1
]}

YONEZAWA, Y ^{[1
]}

UNOKI, K ^{[1
]}

YOSHIMURA, J ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, FAC SCI, CHEM NAT PROD, MIDORI KU, YOKOHAMA 227, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1979年 / 52卷 / 06期

关键词：

D O I：

10.1246/bcsj.52.1657

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several pathways leading to ethyl α-azido-α-alkenoates (8) by the β-elimination to ethyl α-azido-β-substituted (hydroxy-, acetoxy-, or mesyloxy)-alkanoates with NaN3 or Et3N have been examined. The optimized procedure, in combination with subsequent reduction provides a general synthetic route to α-amino-α-alkenoic acid esters (9). The configuration of 8 and 9 have been shown to be of (Z)-geometry.

引用

页码：1657 / 1660

页数：4

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