BETA-ADRENERGIC REGULATION OF CYCLIC-GMP IN RAT PINEALOCYTES

被引：10

作者：

SUGDEN, D

机构：

[1] Biomedical Sciences Division, King's College London, London, W8 7AH, Campden Hill Road, Kensington

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92101-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulation of rat pinealocyte cyclic GMP by β-adrenergic agonists (in the presence of prazosin to block α1-adrenoceptors) showed an identical potency order (isoproterenol> epinephrine = norepinephrine>> salbutamol> terbutaline) to the stimulation of pinealocyte cyclic AMP. The increase in cyclic AMP and cyclic GMP produced by norepinephrine was inhibited by various subtype-selective β-adrenergic antagonists with the same potency order (propranolol> atenolol = ICI 118,551>> practolol). These results indicate that pinealocytes have a single β-adrenoceptor, of the β1-subtype. Activation of this β1-adrenoceptor mediates adrenergic stimulation of not only cyclic AMP but also cyclic GMP. © 1990.

引用

页码：835 / 841

页数：7

共 20 条

[1] NEONATAL RAT PINEALOCYTES - TYPICAL AND ATYPICAL CHARACTERISTICS OF [I-125]IODOHYDROXYBENZYLPINDOLOL BINDING AND ADENOSINE-3',5'-MONOPHOSPHATE ACCUMULATION [J].