TRANSNEURONAL SPREAD OF INTRAPERITONEALLY ADMINISTERED HERPES-SIMPLEX VIRUS TYPE-1 FROM THE ABDOMEN VIA THE VAGUS NERVE TO THE BRAINS OF MICE

被引：10

作者：

KRINKE, GJ

DIETRICH, FM

机构：

[1] Ciba-Geigy Limited, Basel

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 1990年 / 103卷 / 03期

关键词：

D O I：

10.1016/S0021-9975(08)80050-3

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The MacIntyre strain of Herpes simplex virus type 1 was inoculated intraperitoneally into young male mice. Immunohistochemical detection of the virus antigen demonstrated the passage of virus from the gastro-intestinal myenteric plexus towards the brain and its distribution within the areas of brain related to the principal nuclei of the vagus nerve. Selective trapping of the virus in the autonomic nerves and subsequent localization of antigen behind the blood-brain barrier may prevent therapeutic effects of agents tested in this model. © 1990 Academic Press Limited.

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页码：301 / 306

页数：6

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