INHIBITION OF FAST AXONAL-TRANSPORT AND MICROTUBULE POLYMERIZATION INVITRO BY COLCHICINE AND COLCHICEINE

被引：12

作者：

EDSTROM, A

HANSON, M

WALLIN, M

CEDERHOLM, B

机构：

[1] Department of Zoophysiology, University of Lund

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1979年 / 107卷 / 03期

关键词：

Axonal transport; colchiceine; colchicine; energy supply; microtubules;

D O I：

10.1111/j.1748-1716.1979.tb06468.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of colchicine and colchiceine on fast axonal transport in frog sciatic nerves were studied in vitro. Colchiceine inhibited the transport to about the same extent as colchicine. Preincubation at low temperature potentiated the inhibitory effect of either drug. The polymerization of purified brain tubulin was inhibited by colchiceine at 5–10 times higher concentrations than colchicine. The similarity of the effects obtained with colchicine and colchiceine indicates that both drugs arrest axonal transport by interfering with microtubule function. Colchicine and colchiceine did not affect the levels of high energy phosphates (ATP and CrP) in frog nerves indicating that a reduced energy supply was not responsible for the arrested transport. © 1979 Scandinavian Physiological Society

引用

页码：233 / 237

页数：5

共 34 条

[1] CORRELATION BETWEEN EFFECTS OF ANTI-MITOTIC DRUGS ON MICROTUBULE ASSEMBLY INVITRO AND INHIBITION OF AXONAL-TRANSPORT IN NORADRENERGIC NEURONS [J].