IMMUNOHISTOCHEMICAL DETERMINATION OF CD23 EXPRESSION IN HODGKINS-DISEASE USING PARAFFIN SECTIONS

被引：16

作者：

ROWLANDS, DC

HANSEL, TT

CROCKER, J

机构：

[1] E BIRMINGHAM DIST GEN HOSP,DEPT HISTOPATHOL,BORDESLEY GREEN E,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP,DEPT IMMUNOL,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

JOURNAL OF PATHOLOGY | 1990年 / 160卷 / 03期

关键词：

CD23; Hodgkin's lymphoma; immunohistochemistry;

D O I：

10.1002/path.1711600310

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The leukocyte antigen CD23 is expressed during B‐cell development, and functions as an IgE receptor and a lymphocyte growth factor. We studied the expression of CD23 in paraffin sections of lymphoid tissue using the monoclonal antibody BU38. Fifteen cases of Hodgkin's disease, ten reactive lymph nodes, eight B‐cell, and seven T‐cell non‐Hodgkin's lymphomas were analysed immunohistologically. CD23 positivity was seen on follicular dendritic cells and a small number of lymphocytes in reactive nodes. Thirteen of the 15 cases of Hodgkin's disease showed CD23 expression in both neoplastic cells and reactive lymphocytic infiltrate. The antigen was demonstrated in four of the B‐cell of the T‐cell tumours. CD23 may be important in mediating she mixed cellular infiltrate characteristic of Hodgkin's lymphoma. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：239 / &

共 28 条

[1] IMMUNOPHENOTYPING OF HEMATOPOIETIC MALIGNANCIES IN PARAFFIN SECTIONS [J].