DISSOCIATION BETWEEN SYNCYTIA FORMATION AND HIV SPREADING - SUPPRESSION OF SYNCYTIA FORMATION DOES NOT NECESSARILY REFLECT INHIBITION OF HIV-INFECTION

被引:29
作者
PANTALEO, G
POLI, G
BUTINI, L
FOX, C
DAYTON, AI
FAUCI, AS
机构
[1] Laboratory of Immunoregulation, National Institute of Allergy and Infection Diseases, National Institutes of Health, Bethesda
关键词
D O I
10.1002/eji.1830210730
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this study, we have observed that a dissociation may occur in vitro between syncytia formation and HIV spreading. Efficient HIV spreading and virus replication occurred either in HIV-infected LFA-1+ lymphocytes treated with anti-LFA-1 mAb or in HIV-infected lymphocytes genetically deficient in LFA-1, despite the fact that syncytia formation was completely suppressed. Therefore, these results indicate that syncytia formation cannot be used as the sole parameter to evaluate the spread of HIV in vitro.
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页码:1771 / 1774
页数:4
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