NONPHOTIC PHASE-SHIFTING IN HAMSTER CLOCK MUTANTS

被引：75

作者：

MROSOVSKY, N

SALMON, PA

MENAKER, M

RALPH, MR

机构：

[1] UNIV TORONTO,DEPT PHYSIOL,TORONTO M5S 1A1,ONTARIO,CANADA

[2] UNIV TORONTO,DEPT ZOOL,TORONTO M5S 1A1,ONTARIO,CANADA

[3] UNIV VIRGINIA,DEPT BIOL,CHARLOTTESVILLE,VA 22901

来源：

JOURNAL OF BIOLOGICAL RHYTHMS | 1992年 / 7卷 / 01期

关键词：

ACTIVITY; HAMSTER; NONPHOTIC; PHASE RESPONSE CURVE; PHASE SHIFT;

D O I：

10.1177/074873049200700104

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Golden hamsters with the tau mutation were kept in the dark and induced to become active through confinement to a novel running wheel for 3 hr. The response of the mutants to this nonphotic phase-shifting stimulus differed from that of wild-type hamsters. The mutants showed larger phase shifts, and their phase response curves differed in shape, with an advance portion at about circadian time 24, a phase at which wild types show delays. The results establish that the tau mutation, in addition to its already known effects, alters the response of the circadian system to nonphotic events.

引用

页码：41 / 49

页数：9

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