STAPHYLOCOCCUS-MEDIATED T-CELL ACTIVATION AND SPONTANEOUS NATURAL-KILLER-CELL ACTIVITY IN THE ABSENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES

被引：20

作者：

CHAPES, SK ^{[1
]}

HOYNOWSKI, SM ^{[1
]}

WOODS, KM ^{[1
]}

ARMSTRONG, JW ^{[1
]}

BEHARKA, AA ^{[1
]}

IANDOLO, JJ ^{[1
]}

机构：

[1] KANSAS STATE UNIV AGR & APPL SCI,DEPT PATHOL & MICROBIOL,MANHATTAN,KS 66506

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 09期

关键词：

D O I：

10.1128/IAI.61.9.4013-4016.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used major histocompatibility complex class II antigen-deficient transgenic mice to show that in vitro natural killer cell cytotoxicity and T-cell activation by staphylococcal exotoxins (superantigens) are not dependent upon the presence of major histocompatibility complex class II molecules. T cells can be activated by exotoxins in the presence of exogenously added interleukin 1 or 2 or in the presence of specific antibody without exogenously added cytokines.

引用

页码：4013 / 4016

页数：4

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