CHLORTHALIDONE ATTENUATES THE REDUCTION IN TOTAL CHOLESTEROL AND SMALL, DENSE LDL CHOLESTEROL SUBCLASS ASSOCIATED WITH WEIGHT-LOSS

被引：5

作者：

BRADLEY, K ^{[1
]}

FLACK, JM ^{[1
]}

BELCHER, J ^{[1
]}

ELMER, P ^{[1
]}

MILLER, P ^{[1
]}

GRIMM, R ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH PUBL HLTH,DIV EPIDEMIOL,MINNEAPOLIS,MN 55455

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 07期

关键词：

CHLORTHALIDONE; LDL CHOLESTEROL SUBCLASSES; WEIGHT LOSS; CLINICAL TRIAL;

D O I：

10.1093/ajh/6.7.636

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Thiazide diuretics are known to raise total and LDL cholesterol. To assess whether chlorthalidone affected levels of putatively atherogenic small, dense LDL (LDL 3), we conducted a 12 week double blind randomized, placebo controlled clinical trial in 34 nonsmoking men aged 35 to 57 years with mild hypertension (DBP 90 to 104 mm Hg). Our a priori hypothesis that chlorthalidone raised LDL 3 levels was not confirmed. However, the fall in LDL 3 (P = .03) and total cholesterol (P = .08) associated with weight loss was attenuated by chlorthalidone. Since weight loss is commonly prescribed during the clinical management of hypertensives with concomitant hypercholesterolemia, consideration should be given to the attenuating effect of chlorthalidone on cholesterol reduction in the management of these patients.

引用

页码：636 / 639

页数：4

共 11 条

[1]

Ames R.P., Hill P., Increase in serum lipids during treatment of hypertension with chlorthalidone, Lancet, 1, pp. 721-723, (1976)

[2]

Grimm R.H., Leon A.F., Hunninghake D.B., Effects of thiazide diuretics on plasma lipids and lipoproteins in mildly hypertensive patients, Am Intern Med, 94, pp. 7-11, (1981)

[3]

Rosenthal T., Holtzman E., Segal P., The effect of chlorthalidone on serum lipids and lipoproteins, Atherosclerosis, 36, pp. 111-115, (1980)

[4]

Goldman A.I., Steele B.W., Schnaper H.W., Serum lipoprotein levels during chlorthalidone therapy: A Veterans Administration-National Heart, Lung, and Blood Institute cooperative study on antihypertensive therapy: Mild hypertension, JAMA, 244, pp. 1691-1695, (1980)

[5]

Austin M.A., Low density lipoprotein subclass patterns and risk of myocardial infarction, JAMA, 260, pp. 1917-1921, (1988)

[6]

Crouse J.R., Parks J.S., Schey H.M., Kahl F.R., Studies of low density lipoprotein molecular weight in human beings with coronary artery disease, J Lipid Res, 26, pp. 566-574, (1985)

[7]

Campos H., McNamara J.R., Wilson P., Differences in low density lipoprotein subfractions and apolipoproteins in premenopausal and postmenopausal women, J Clin Endocrinol Metab, 67, pp. 30-35, (1988)

[8]

Belcher J.D., Egan J., Bridgeman G., A micro-enzymatic method to measure cholesterol and triglyceride in lipoprotein subfractions separated by density gradient ultracentrifugation from 200 microliters of plasma or serum, J Lipid Res, 32, pp. 359-369

[9]

Williams P.T., Krauss R.M., Vranizan K.M., Effects of exercise-induced weight loss on low density lipoprotein subfractions in healthy men, Arteriosclerosis, 9, pp. 623-632, (1989)

[10]

Gluck Z., Weidman P., Mordasini R., Increased serum low-density lipoprotein cholesterol in men treated shortterm with the diuretic chlorthalidone, Metabolism, 29, pp. 240-245, (1980)

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