GLYCINE CODON DISCRIMINATION AND THE NUCLEOTIDE IN POSITION-32 OF THE ANTICODON LOOP

被引:37
作者
CLAESSON, C
LUSTIG, F
BOREN, T
SIMONSSON, C
BARCISZEWSKA, M
LAGERKVIST, U
机构
[1] GOTHENBURG UNIV, DEPT MED BIOCHEM, S-41390 GOTHENBURG, SWEDEN
[2] POLISH ACAD SCI, INST BIOORGAN CHEM, PL-60704 POZNAN, POLAND
关键词
ANTICODON; TRANSFER RNA; WOBBLE POSITION; FAMILY CODON BOX; GLYCINE;
D O I
10.1006/jmbi.1994.0132
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using an in vitro protein-synthesizing system that allowed us to monitor separately-the reading of each glycine codon, we have previously shown, that in constructs based on glycine tRNA(1) from Escherichia coli the nature of the nucleotide in position 32 determines the ability of the anticodon UCC to discriminate between the glycine codons. Thus, with a U in position 32 the anticodon UCC discriminated according to the wobble rules, but with a C in this position it had lost its ability to discriminate. In the present paper we show that the same is true also for constructs based on mycoplasma glycine tRNA. When C32 in the wild type was changed to U32, the anticodon UCC discriminated between the glycine codons, while in wild type mycoplasma glycine tRNA it did not. Furthermore, when U32 was changed to C32 in glycine tRNA(1) (CCC), the anticodon CCC loses its ability to discriminate. We therefore conclude that the nature of the nucleotide in position 32 determines the discriminatory ability of both anticodons UCC and CCC in the glycine tRNA(1) structural background, and that the same is true for the anticodon UCC in the mycoplasma glycine tRNA background.
引用
收藏
页码:191 / 196
页数:6
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