PROTECTIVE EFFECTS OF KW-3902, A NOVEL ADENOSINE A(1)-RECEPTOR ANTAGONIST, AGAINST GENTAMICIN-INDUCED ACUTE-RENAL-FAILURE IN RATS

被引：20

作者：

YAO, K ^{[1
]}

KUSAKA, H ^{[1
]}

SATO, K ^{[1
]}

KARASAWA, A ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,DEPT TOXICOL,NAGAIZUMI,SHIZUOKA 411,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1994年 / 65卷 / 02期

关键词：

KW-3902; ADENOSINE A(1)-RECEPTOR ANTAGONIST; ACUTE RENAL FAILURE;

D O I：

10.1254/jjp.65.167

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the possible renal protective effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), an adenosine A(1)-receptor antagonist, against gentamicin (GM)-induced acute renal failure (ARF) in rats. ARF was induced by subcutaneous injection of GM at 80 mg/kg/day for 12 days. KW-3902 (0.001-0.1 mg/kg, p.o., twice daily) attenuated the increases of serum creatinine and urea nitrogen and the decrease of creatinine clearance in rats treated with GM. In contrast, furosemide and trichlormethiazide aggravated the GM-induced nephrotoxicity. These results suggest that KW-3902 can ameliorate the GM-induced ARF and that endogenous adenosine may be involved in GM-induced ARF via the adenosine A(1)-receptor.

引用

页码：167 / 170

页数：4

共 15 条

[1] AMINOGLYCOSIDE NEPHROTOXICITY [J].

APPEL, GB .

AMERICAN JOURNAL OF MEDICINE, 1990, 88 (3C) :S16-S20

[2]

BIDANI AK, 1986, CAN J PHYSL PHARM, V65, P42

[3] CHANGES OF ADENOSINE LEVELS IN THE CAROTID-ARTERY, RENAL-VEIN AND INFERIOR VENA-CAVA AFTER GLYCEROL OR MERCURY INJECTION IN THE RAT [J].

ISHIKAWA, I ;

SHIKURA, N ;

TAKADA, K ;

SATO, Y .

NEPHRON, 1993, 64 (04) :605-608

[4] AMINOGLYCOSIDE-INDUCED FUNCTIONAL AND BIOCHEMICAL DEFECTS IN THE RENAL CORTEX [J].

KALOYANIDES, GJ .

FUNDAMENTAL AND APPLIED TOXICOLOGY, 1984, 4 (06) :930-943

[5] EFFECT OF ALKYLXANTHINES ON GENTAMICIN-INDUCED ACUTE RENAL-FAILURE IN THE RAT [J].

KELLETT, R ;

BOWMER, CJ ;

COLLIS, MG ;

YATES, MS .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (12) :849-854

[6] AMELIORATION OF CISPLATIN-INDUCED ACUTE-RENAL-FAILURE WITH 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE [J].

KNIGHT, RJ ;

COLLIS, MG ;

YATES, MS ;

BOWMER, CJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (04) :1062-1068

[7] STUDIES ON THE NEPHROTOXICITY OF AMINOGLYCOSIDE ANTIBIOTICS AND PROTECTION FROM THESE EFFECTS .2. PROTECTIVE EFFECT OF LATAMOXEF AGAINST GENTAMICIN-NEPHROTOXICITY [J].

KOJIMA, R ;

SUZUKI, Y .

FOLIA PHARMACOLOGICA JAPONICA, 1984, 84 (05) :463-469

[8] RENAL TUBULAR SITE OF ACTION OF KW-3902, A NOVEL ADENOSINE A(1)-RECEPTOR ANTAGONIST, IN ANESTHETIZED RATS [J].

MIZUMOTO, H ;

KARASAWA, A .

JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 61 (03) :251-253

[9]

MIZUMOTO H, 1993, J PHARMACOL EXP THER, V266, P200

[10]

MIZUMOTO H, 1992, JPN J PHARM S1, V58, pP194

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