BETA-ENDORPHIN AND ACTH - OPIATE PEPTIDES WITH COORDINATED ROLES IN THE REGULATION OF BEHAVIOR

被引：23

作者：

JACQUET, YF

机构：

来源：

TRENDS IN NEUROSCIENCES | 1979年 / 2卷 / 06期

关键词：

D O I：

10.1016/0166-2236(79)90056-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

From her behaviour-related studies, Yasuko Jacquet suggests that there are two classes of opiate receptor in the periaqueductal grey region of the midbrain. The ligand for one is β-endorphin and, for the other, corticotropin. These observations provide important implications for the treatment and prevention of opiate addiction. Furthermore, the concept of a dual receptor mechanism helps in the interpretation of a number of observations of behaviour in the postaddiction or 'abstinence' state. © 1979.

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页码：140 / 143

页数：4

相关论文

共 9 条

[1] OPIATE EFFECTS AFTER ADRENOCORTICOTROPIN OR BETA-ENDORPHIN INJECTION IN PERIAQUEDUCTAL GRAY-MATTER OF RATS [J].

JACQUET, YF .

SCIENCE, 1978, 201 (4360) :1032-1034

[2] PARADOXICAL EFFECTS AFTER MICROINJECTION OF MORPHINE IN PERIAQUEDUCTAL GRAY MATTER IN RAT [J].

JACQUET, YF ;

LAJTHA, A .

SCIENCE, 1974, 185 (4156) :1055-1057

[3] STEREOSPECIFIC AND NON-STEREOSPECIFIC EFFECTS OF (+)-MORPHINE AND (-)-MORPHINE - EVIDENCE FOR A NEW CLASS OF RECEPTORS [J].

JACQUET, YF ;

KLEE, WA ;

RICE, KC ;

IIJIMA, I ;

MINAMIKAWA, J .

SCIENCE, 1977, 198 (4319) :842-845

[4] C-FRAGMENT OF BETA-LIPOTROPIN - ENDOGENOUS NEUROLEPTIC OR ANTIPSYCHOTOGEN [J].

JACQUET, YF ;

MARKS, N .

SCIENCE, 1976, 194 (4265) :632-635

[5] COMMON PRECURSOR TO CORTICOTROPINS AND ENDORPHINS [J].

MAINS, RE ;

EIPPER, BA ;

LING, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) :3014-3018

[6] SURGERY IN RAT DURING ELECTRICAL ANALGESIA INDUCED BY FOCAL BRAIN STIMULATION [J].

REYNOLDS, DV .

SCIENCE, 1969, 164 (3878) :444-&

[7] SOMATOSTATIN AND ACTH ARE PEPTIDES WITH PARTIAL ANTAGONIST-LIKE SELECTIVITY FOR OPIATE RECEPTORS [J].

TERENIUS, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1976, 38 (01) :211-213

[8] EVIDENCE FOR 2 SEPARATE OPIATE PEPTIDE NEURONAL SYSTEMS [J].

WATSON, SJ ;

AKIL, H ;

RICHARD, CW ;

BARCHAS, JD .

NATURE, 1978, 275 (5677) :226-228

[9]

WAY EL, 1976, OPIATES ENDOGENOUS O, P311